TABLE 2.
Pharmacokinetic parameters corresponding to the two-compartment population model depicted in Fig. 1
| Population parametera | Value |
|
|---|---|---|
| Typical | IIV (%) | |
| CL (liters/h) (RSE%) | 3.6 (15.7) | 71.2 |
| V1 (liters) (RSE %) | 7.3 (11.8) | 57.8 |
| Q (liters/h) (RSE %) | 6.58 (16.4) | |
| V2 (liters) (RSE %) | 3.9 (9.7) | |
| βPcrea (liters/h)/(μmol/liter) (RSE %) | −0.011 (11.9) | |
| Proportional error (%) (RSE %) | 14.7 (14.4) | |
| Cmax (mg/liter) [median (IQR)] | 546 (363; 668) | |
| Cmin (mg/liter) [median (IQR)] | 51.7 (10.7; 159.4) | |
| AUC0–8 (mg/liter · h) [median (IQR)] | 1,148 (739; 2,492) | |
| t1/2 (h) [median (IQR)] | 3.49 (1.62; 4.47) | |
a
RSE, relative standard error reported on the approximate standard deviation scale; IIV, interindividual variability expressed as coefficient of variation; CL, clearance; V1, central volume; Q, intercompartmental clearance; V2, peripheral volume; βPcrea, covariate between clearance and plasma creatinine level (Pcrea), with clearance given by CLi = CL + βPcrea · (Pcrea − 170 μmol/liter); Cmax, maximum predicted plasma concentration; Cmin, trough predicted plasma concentration; AUC0–8, area under the plasma concentration-time curve from 0 to 8 h after the studied dose; t1/2, terminal half-life.