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Aminoglycoside susceptibility is suppressed by chemically arresting translation or transcription. Translation and transcription were inhibited by pretreating stationary-phase cultures for 30 min with subinhibitory levels of chloramphenicol and rifampin, respectively. Data are from 72 h. GEN, gentamicin (10 μg/ml); CM, chloramphenicol (20 μg/ml); RIF, rifampin (20 μg/ml). Means and SDs (n ≥ 3) are presented. Dashed line, limit of detection of 100 CFU/ml.
