TABLE 5.

Animal efficacy of lead compounds in an S. pneumoniae intraperitoneal challenge infection model in mice

Compound	S. pneumoniae WT serum MIC (μg/ml)a		% survival for i.p. challenge model in miceb
	None	Mouse
8	0.25	0.25	100
27 (omadacycline)	<0.06	<0.06	100
28	0.125	0.5	100
30	<0.06	<0.06	100
31	<0.06		100
23	0.125	0.25	100
34	0.25	0.25	100
10	<0.06	0.125	100
40	<0.06	0.25	80
42	0.125	4	100
Minocycline	<0.06	0.125	100
Tigecycline	<0.06	<0.06	100

^aMIC against S. pneumoniae 157E in the absence or presence of 50% mouse serum.

^bEfficacy in S. pneumoniae 157E intraperitoneal challenge infection model in CD-1 mice. Compounds were screened at 5 mg/kg via single subcutaneous injection. Percent survival was measured versus untreated animal group at 7 days postinfection.