TABLE 4.
Comparison of time to AKI by UrNGAL criterion versus SCr criteriona
| UrNGAL criterion | No. of patients included in analysis | Time to AKI (days) |
Time to peak concn (days) |
Difference in time to AKI or peak concn (days) | P value | ||
|---|---|---|---|---|---|---|---|
| UrNGAL criterion | KDIGObin criterion | UrNGAL | SCr | ||||
| UrNGAL concn | |||||||
| ≥2.54 ng/ml | 11 | 5.2 ± 3.8 | 6.9 ± 3.5 | −1.7 | 0.060 | ||
| ≥3 times baseline level | 13 | 3.7 ± 2.5 | 6.9 ± 3.3 | −3.2 | 0.001 | ||
| Peak UrNGAL concn | 17 | 6.8 ± 3.3 | 8.2 ± 3.4 | −1.5 | 0.035 | ||
a
AKI, acute kidney injury; UrNGAL, urine neutrophil gelatinase-associated lipocalin; SCr, serum creatinine; KDIGObin criterion, Kidney Disease: Improving Global Outcomes criterion that requires an increase in the SCr level by ≥0.3 mg/dl within 48 h or an increase in the SCr level to ≥1.5 times the baseline level which is known or presumed to have occurred within the prior 7 days.