TABLE 1.
MICs of β-lactams for P. aeruginosa NCGM3025 and E. coli transformants containing blaIMP-7 and blaIMP-51
| Antibiotic(s)a | MIC (μg/ml) of antibiotic for: |
|||
|---|---|---|---|---|
| P. aeruginosa NCGM3025 | E. coli DH5α(pHSG398/IMP-7) | E. coli DH5α(pHSG398/IMP-51) | E. coli DH5α(pHSG398) | |
| Ampicillin | >1,024 | 128 | 32 | 8 |
| Ampicillin-sulbactam | 512 | 64 | 8 | 4 |
| Penicillin G | >1,024 | 128 | 32 | 32 |
| Aztreonam | 32 | 0.063 | 0.063 | 0.063 |
| Cefepime | 256 | 8 | 8 | 0.063 |
| Cefotaxime | 1,024 | 32 | 64 | 0.031 |
| Cefoxitin | >1,024 | 512 | >2,048 | 16 |
| Cefozopran | 256 | 16 | 8 | 0.125 |
| Cefpirome | 32 | 2 | 0.5 | ≤0.007 |
| Ceftazidime | 256 | 512 | 128 | 0.5 |
| Ceftriaxone | >1,024 | 64 | 128 | 0.031 |
| Cephradine | >1,024 | 512 | 64 | 16 |
| Doripenem | 256 | 2 | 4 | 0.031 |
| Imipenem | 16 | 0.25 | 0.25 | 0.031 |
| Meropenem | 512 | 1 | 4 | 0.015 |
| Panipenem | 16 | 0.25 | 0.25 | 0.063 |
| Moxalactam | >1,024 | 256 | 1,024 | 0.125 |
a
The ratio of ampicillin to sulbactam was 2:1.