TABLE 2.
Significant hits from RNA-seq analysis
| Gene | Mutant 1 + MP-III-71 vs complement + MP-III-71 |
Mutant 1 + DMSO vs complement + DMSO |
TubercuList annotation | ||
|---|---|---|---|---|---|
| Log2 fold change | Adjusted P value | Log2 fold change | Adjusted P value | ||
| Rv0560c | −7.67 | 6.98E−58 | 0.00 | 3.29E−53 | Possible benzoquinone methyltransferase (methylase) |
| Rv2887 | 7.16 | 4.38E−20 | 75.40 | 1.38E−12 | |
| Rv0558 | −3.06 | 1.16E−12 | 0.08 | 1.96E−14 | MenH (probable ubiquinone/menaquinone biosynthesis methyltransferase MenH) |
| Rv0559c | −3.63 | 4.70E−11 | 0.05 | 3.38E−13 | Possible conserved secreted protein |
| Rv2463 | −1.59 | 0.01 | 0.35 | 0.02 | LipP (probable esterase/lipase) |
| Rv2886c | 2.34 | 0.03 | 3.28 | 1.00 | Probable resolvase |