TABLE 6.

Variants in NS3/4A and NS5A at resistance-associated amino acid positions in patients experiencing virologic failure

Patienta	Failure typeb	NS3/4A				NS5A
		Baseline	Virologic failure	PTW24	PTW48	Baseline	Virologic failure	PTW24	PTW48
1	OTVF at wk 8	Nonec	Y56H+ D168V	Noned	NDe	None	L28V	L28V/L	Noned
2	Relapse at PTW4	None	D168V	D168Vd	Noned	T58P	L28S, M31I/M, T58P	L28S+M31I+T58P	L28S/L, M31I/M, T58P
3	Relapse at PTW8	None	D168V	D168V	Noned	T58T/S	L28V+T58S	L28V, T58T/S	L28V+T58S

^aAll three patients were infected with HCV genotype 4d.

^bOTVF, on-treatment virologic failure; PTW, posttreatment week.

^cNone, variants at resistance-associated amino acid positions were not detected.

^dDetermined by clonal sequencing analysis; includes variants detected in ≥2 clones.

^eND, sequence not determined because resistance-associated variants were not detected at the previous time point.