TABLE 2.

Plasma extraction efficiency of atazanavir, ritonavir, and tenofovir^a

Parameter	Data for drugs by dose (ng/ml)
	Atazanavir			Ritonavir			Tenofovir
	5	50	750	5	50	750	5	50	750
Calculated concn (ng/ml) for run:
1	4.85	42.12	785.60	5.17	49.41	784.15	4.81	48.73	682.82
2	4.55	44.92	746.24	4.99	51.50	739.56	5.27	51.45	758.56
3	4.76	50.71	762.47	5.35	54.27	750.69	5.32	44.00	746.56
4	4.13	48.52	767.89	4.79	43.10	758.97	4.42	47.86	761.30
5	4.65	46.24	738.54	5.25	44.65	724.27	4.42	44.27	728.28
6	4.71	49.27	760.28	4.92	46.36	727.40	4.78	48.99	756.36
Avg concn (ng/ml)	4.61	46.96	760.17	5.08	48.21	747.51	4.84	47.55	738.98
SD	0.26	3.16	16.58	0.21	4.27	22.32	0.39	2.90	30.03
%CV	5.56	6.73	2.18	4.21	8.86	2.99	8.16	6.10	4.06
% recovery	92.10	93.93	101.36	101.55	96.42	99.67	96.76	95.10	98.53

^aValues are given as calculated concentrations, with spiked extracted blank plasma representing 100%.