TABLE 5.
Intracellular drug concentrations in mononuclear cells isolated from the whole blood of primates dosed subcutaneously with atazanavir (20 mg/kg), ritonavir (10.2 mg/kg), and tenofovir (12.2 mg/kg)
| Drug or parameter | Dataa for drugs by time (h) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Atazanavir |
Ritonavir |
Tenofovir |
||||||||||
| 0 | 1 | 5 | 8 | 0 | 1 | 5 | 8 | 0 | 1 | 5 | 8 | |
| R10125 | 0.0 | 151.0 | 166.3 | 65.4 | 0.0 | 124.5 | 544.2 | 366.4 | 0.0 | 3,523.5 | 838.5 | 338.3 |
| T10111 | 0.0 | 132.7 | 228.5 | 153.4 | 0.0 | 106.4 | 1,012.7 | 745.1 | 0.0 | 4,689.4 | 660.9 | 377.5 |
| Avg | 0.0 | 141.8 | 197.4 | 109.4 | 0.0 | 115.4 | 778.4 | 555.8 | 0.0 | 4,106.4 | 749.7 | 357.9 |
| SD | 0.0 | 9.1 | 31.1 | 44.0 | 0.0 | 9.1 | 234.3 | 189.4 | 0.0 | 583.0 | 88.8 | 19.6 |
a
Concentration (picograms per million cells).