TABLE 1.

Activity of elbasvir against HCV genotype 1 NS5A variant replicons^a

Sequence identificationb	Effective inhibitory concn (nM)c
	50%	90%
1a_H77	0.004 ± 0.002	0.006 ± 0.002
1a_H77 in 40% NHS	0.040 ± 0.013	0.082 ± 0.027
1a DQ889262	0.009 ± 0.007	0.019 ± 0.012
1a DQ889305	0.005 ± 0.000	0.011 ± 0.004
1a DQ889320	0.003 ± 0.000	0.009 ± 0.005
1a EU155348	0.003 ± 0.002	0.007 ± 0.001
1a EU155380	0.006 ± 0.001	0.015 ± 0.004
1b_con1	0.003 ± 0.001	0.006 ± 0.004
1b AF033358	0.005 ± 0.003	0.012 ± 0.006
1b AJ132996	0.009 ± 0.005	0.019 ± 0.011
1b B9016	0.014 ± 0.006	0.029 ± 0.009
1b EU482860	0.010 ± 0.004	0.026 ± 0.013

^aA convenience sample of genotype 1 isolates available in the public domain was used to test susceptibility to elbasvir in the replicon assay. The table summarizes the results from cell lines that were able to replicate in cell culture.

^bNumbers are GenBank accession numbers except for 1b B9016. H77 and con1 are wild-type referents for genotypes 1a and 1b, respectively. NHS, normal human serum.

^cValues are averages and ranges from duplicate independent experiments.