TABLE 2.

Activity of elbasvir against HCV genotype 3 replicons^a

Sequence identificationb	Con1 backbone		JFH backbone
	No. of replicon colonies	Meanc EC90 ± SD (nM)	No. of replicon colonies	Meanc EC90 ± SD (nM)
Parental replicon	300	0.006 ± 0.004	TMTC	0.019 ± 0.010
GU814823 (S52)	9	0.042 ± 0.011	503	0.065 ± 0.026
GQ356207	3	0.016 ± 0.008	472	0.035 ± 0.027
AM493639	0	ND	0	ND
EU826291	21	0.005 ± 0.003	TMTC	0.096 ± 0.117
EU826299	0	ND	0	ND
GQ300882	0	ND	482	0.613 ± 0.855
GQ356215	0	ND	242	0.016
HM042077	2	0.011 ± 0.010	598	0.034 ± 0.037
HM042078	4	0.007 ± 0.006	412	0.031 ± 0.022
HQ912953	2	0.007 ± 0.004	51	0.016
AF320799	0	0.119	43	0.387 ± 0.380
NC_009824	ND	0.120 ± 0.060	ND	ND

^aEC, effective (inhibitory) concentration; TMTC, too many to count; ND, not done.

^bNumbers are GenBank accession numbers. Parental replicons of con1 (genotype 1b) and JFH (genotype 2a) were used as controls.

^cAverage from ≥3 independent experiments.