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Replicative capacity (fitness) of variants in genotype 1a_H77 or genotype 1b_con1 replicons
| Genotype | Replicon variation | Fitness (% of wild-type control replication) |
|---|---|---|
| 1a | H77 (WT) | 100 |
| Q30D | 70 | |
| Q30E | 57 | |
| Q30K | 100 | |
| L31V | 41 | |
| Y93N | 6 | |
| Y93H | 1 | |
| Q30D_Y93N | 15 | |
| 1b | con1 (WT) | 100 |
| L31F | 0.1 | |
| L31V | 1.7 | |
| Y93C | 0.5 | |
| Y93H | 0.5 | |
| 3a | S52 (WT) | 100 |
| Y93H | 50 |
