TABLE 1.

Simulated dosing scenarios

Dosing regimena	Drug formulary
25 mg/kg q12h for children between 1 and 3 mo old	British National Formulary for Children (19)
25 mg/kg q8h for children older than 3 mo	British National Formulary for Children (19)
25 mg/kg q6hb	Sanford Guide for Antimicrobial Therapy (9)
25 mg/kg q4hc

^aThe dosing regimen was based on the amoxicillin component and a fixed ratio of amoxicillin-clavulanic acid of 5:1. All simulations included a bolus and 1-h infusion regimen. Abbreviations: q12h, every 12 h; q8h, every 8 h; q6h, every 6 h; q4h, every 4 h.

^bStudy dosing regimen.

^cNewly tested dosing regimen.