Table 4. Network parameters in Hepatitis E, SARS and herpesviruses.

Network Parameters	HEVY2H	HEVLuMPIS	SARS	HSV-1	VZV	mCMV	EBV	KSHV
#Proteins	16	9	31	48	57	111	61	50
#Interactions	35	20	65	111	173	406	218	123
#Interactions (w/o self-interactions)	26	15	59	100	160	393	208	115
Average degreea	4.38	4.44	4.19	4.63	6.07	7.32	7.15	4.92
Average degree (w/o self-interactions)	3.25	3.33	3.81	4.17	5.61	7.08	6.82	4.60
Characteristic path lengthb	1.65	1.64	2.43	2.79	2.34	2.84	2.44	2.84
Diameterc	3.00	3.00	5.00	6.00	5.00	7.00	5.00	7.00
Clustering coefficientd	0.71	0.77	0.41	0.25	0.39	0.24	0.40	0.15
Enrichment over ER	2.44	1.39	2.94	2.53	3.65	3.68	3.35	1.45
Enrichment over ES	1.36	NA	0.99	0.79	1.00	1.23	1.14	0.69

^aAverage degree: number of interactions per proteins.

^bCharacteristic path length average shortest path length.

^cDiameter: maximum shortest path length.

^dClustering coefficient and enrichment of clustering coefficient compared to the average of 1000 random graphs of the same size (ER) and 1000 random networks with the same degree distribution (ES). For the Hepatitis E LuMPIS network, enrichment over ES could not be calculated due to its small size. Self-interactions were not included for the computation of average clustering coefficients, characteristic path length and network diameter as well as enrichment values.