Figure 4. CCl₄ induced liver damage enhances the secretion polyreactive antibodies.

Two months old mice (n = 5) were injected with 2 ml/kg body weight of CCl₄ i.p. (A) Histopathology and (Original magnification X10) (B) elevated serum ALT levels show the induction of liver damage (Mann-Whitney U test) in both C57BL/6 wild type and MyD88 null mice. (C) Polyreactive antibody titer increases after injection of CCl₄ in wild type mice, but not MyD88 null mice. Mean ± SEM (n = 5 mice per group, ANOVA).