Table 2.

FEV₁ trough and AUC_0–6 responses after 4 weeks of treatment (full analysis set)

Treatment	Trough FEV1 mean (SE) response, L	Difference from O monotherapy, L (95% CI)	P value	FEV1 AUC0–6 mean (SE) response, L	Difference from O monotherapy, L (95% CI)	P value
O 5 μg	0.071 (0.018)			0.188 (0.020)
+T 1.25 µg	0.125 (0.018)	0.054 (0.016, 0.092)	0.0057	0.267 (0.020)	0.078 (0.040, 0.117)	<0.0001
+T 2.5 μg	0.136 (0.018)	0.065 (0.027, 0.103)	0.0009	0.287 (0.020)	0.099 (0.060, 0.137)	<0.0001
+T 5 μg	0.155 (0.018)	0.084 (0.046, 0.122)	<0.0001	0.307 (0.020)	0.118 (0.080, 0.157)	<0.0001
O 10 μg	0.083 (0.018)			0.198 (0.020)
+T 1.25 µg	0.134 (0.018)	0.051 (0.013, 0.089)	0.0092	0.296 (0.020)	0.098 (0.060, 0.136)	<0.0001
+T 2.5 μg	0.166 (0.018)	0.083 (0.045, 0.122)	<0.0001	0.320 (0.020)	0.121 (0.083, 0.159)	<0.0001
+T 5 μg	0.163 (0.018)	0.080 (0.042, 0.119)	<0.0001	0.342 (0.020)	0.144 (0.105, 0.182)	<0.0001

AUC _0–6 area under the curve from 0 to 6 h, CI confidence interval, FEV ₁ forced expiratory volume in 1 s, O olodaterol, SE standard error, T tiotropium