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. 2015 Oct 14;8:62. doi: 10.1186/s12920-015-0139-4

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© Zhao et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Distribution of hyper-DMRs or hypo-DMRs in different genomic elements. a, b Left panel: Each bar represents the fraction of hyper-DMRs (or hypo-DMRs) map to each genomic element in SZ (a) and BD (b). Right panel: The x axis indicates O/E ratios between the observed and expected number of DMRs overlapping with a given type of genomic elements. The average number of DMRs in random sets overlapping with a given type of genomic elements was regarded as the expected value. Asterisks indicating the significance levels (* represents P < 0.05; ** represents P < 0.01). c, d Comparisons between differentially expressed genes and genes with aberrant DNA methylation in different genomic elements in SZ (c) and BD (d). Distribution of up- and down-regulated genes (left), and genes with hyper-DMRs (middle) or hypo-DMRs (right) located in their different genomic elements. For each type of genes, red indicates present