Table 1.

Characteristics of included articles

Characteristics	n = 128 (%)
Study design
Prospective	42 (33 %)
Before–after	40 (31 %)
Historical cohort	39 (30 %)
Cross-sectional	6 (5 %)
Other	1 (1 %)
Therapeutic intervention
Drug	51 (40 %)
Surgery	14 (11 %)
Device or equipment	14 (11 %)
Behavioral intervention or participative	20 (16 %)
Therapeutic strategy	29 (23 %)
Comparator
Placebo or attention control intervention	4 (3 %)
Active treatment	55 (43 %)
Usual care or no treatment	25 (20 %)
No comparator or Unclear	44 (34 %)
Sample size, median [Q1–Q3], (range)	129.5 [50.75–457.5], (5–238600)
Funding source
Profit	28 (22 %)
Not for profit	54 (42 %)
Both	5 (4 %)
Not reported or unclear	41 (32 %)
Registration
Yes	39 (30 %)
No or not reported	89 (70 %)