Table 1.
Cytotoxicity (LC50 in µg/mL) and the selectivity index (SI) of three limonoids isolated from Trichilia welwitschii and reference compounds (doxorubicin and puromycin) against cancer cell lines
| Compounds | Vero | THP-1 | RAW 264.7 | ||
|---|---|---|---|---|---|
| LC50 | SI | LC50 | SI | ||
| 1 | 89.17 ± 5.00a | 81.20 ± 6.38a | 0.87 | 23.55 ± 5.77a | 2.99 |
| 2 | 85.22 ± 6.31a | 81.20 ± 4.04a | 0.87 | 65.68 ± 3.64b | 1.07 |
| 3 | 75.82 ± 1.85b | 84.53 ± 5.81a | 0.83 | 61.86 ± 4.14b | 1.14 |
| Doxorubicin | 9.35 ± 0.66c | nd | nd | 1.06 ± 0.65c | 66.42 |
| Puromycin | 5.32 ± 0.90d | 0.4 ± 0.02b | 176.03 | 1.15 ± 0.17c | 61.23 |
Values with different letters are significantly different at p < 0.05
nd not determined