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. 2015 Oct 13;15:685. doi: 10.1186/s12885-015-1672-4

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© Adkins et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Representative image of 231Br brain metastases (a) and corresponding ¹⁴C-Irinotecan accumulation (b) in metastases 2 h after intravenous administration of radiolabeled irinotecan. Representative image of 231Br brain metastases (c) and corresponding ¹⁴C-NKTR-102 accumulation (d) in metastases 6 h after intravenous administration of radiolabeled NKTR-102. ¹⁴C-irinotecan concentration versus 231Br lesion size in individual metastases (e). ¹⁴C-NKTR-102 concentration versus 231Br lesion size in individual metastases (f). Dashed line in panel (e) and f represents mean BDT ¹⁴CIrinotecan and ¹⁴C-NKTR-102 concentration respectively. Mean BDT and lesion accumulation of ¹⁴C-Irinotecan (white columns) and ¹⁴C-NKTR-102 (black columns) (g). Mean lesion accumulations of ¹⁴C-Irinotecan and ¹⁴C-NKTR-102 were significantly different. All data are Mean ± SEM (n = 8-10)