Skip to main content
. 2015 Aug 26;7(10):1251–1253. doi: 10.15252/emmm.201505551

Figure 1. Sema3 proteins display vascular normalizing properties.

Figure 1

Secreted Sema3A (Maione et al, 2009), Sema3C (Yang et al, 2015), and Sema3F (Wong et al, 2012) promote the functional normalization of pathological blood vessels that are devoid of pericyte ensheathment. Of note, both Sema3A (Maione et al, 2009) and Sema3C (Yang et al, 2015) appear to selectively elicit the apoptosis EC belonging to immature, but not mature blood vessels (upper panel). In addition, Sema3A has chemoattractive activity towards cultured SMCs (Maione et al, 2009), supporting the hypothesis that at least this Sema3 may also favour the recruitment of pericytes on immature blood vessels (lower panel).