Fig. 1.

Effects of cardiac remodelling on chronic hypertension and, after experimental myocardial infarction (MI), on transforming growth factor beta-stimulated clone 22 (TSC-22) expression. a Left ventricular (LV) tissue TSC-22 total protein levels were analysed by Western blot from 12 and 20 months old Wistar Kyoto (WKY) and spontaneously hypertensive rat (SHR) hearts (n = 5). Open bars represent WKY and solid bars SHR *P<0.05 versus WKY (Student’s t-test). The effect of MI on LV tissue TSC-22 mRNA levels (b) measured by Northern blot or RT-PCR and TSC-22 protein levels (c) analysed by Western blot (n = 6−8). Open bars represent sham and solid bars MI *P<0.05, **P <0.01, ***P <0.001 versus sham (Student’s t-test). The results are expressed as mean ± SEM. Representative Western blots are shown