Fig. 2.
The effect of acute and chronic pressure overload on transforming growth factor beta-stimulated clone 22 (TSC-22) gene expression. a The effect of angiotensin II (Ang II) administration (33 μg/kg/h) on left ventricular (LV) TSC-22 mRNA levels assessed by Northern blot analysis in rats (n = 6−8). Open bars represent control and black bars Ang II ***P <0.001 versus control (Student’s t-test). b TSC-22 mRNA levels after arginine vasopressin (AVP) infusion (n = 9). Open bars represent control and solid bars AVP *P <0.05, ***P <0.001 versus control (Student’s t-test). c The effect of Ang II and AT1-receptor antagonist losartan (Los) on LV TSC-22 mRNA levels at 6 h (n = 5−8). *P <0.05, ***P <0.001 versus control. ƗƗƗ P <0.001 versus Ang II (one-way ANOVA followed by least significance difference post hoc test). The results are expressed as mean ± SEM. Representative Northern blots are shown