Table 2.
Associations between several factors and chemotherapy-induced nausea and vomiting
| Factor | Moderate/severe nausea (CTC grade 2, 3) | Vomiting | Severe appetite suppression (CTC grade 3) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes | No | p value (Fisher’s exact test) | Yes | No | p value (Fisher’s exact test) | Yes | No | p value (Fisher’s exact test) | |
| Age | |||||||||
| < 59 | 4 | 7 | 1.000 | 3 | 8 | 0.332 | 7 | 4 | 1.000 |
| 60 ≤ | 3 | 4 | 4 | 3 | 5 | 2 | |||
| Gender | |||||||||
| Male | 2 | 9 | 0.049 | 2 | 9 | 0.049 | 6 | 5 | 0.316 |
| Female | 5 | 2 | 5 | 2 | 6 | 1 | |||
| KPS | |||||||||
| 60–70 | 2 | 2 | 1.000 | 2 | 2 | 1.000 | 2 | 2 | 0.569 |
| 80–100 | 5 | 9 | 5 | 9 | 10 | 4 | |||
| Pathology | |||||||||
| WHO grade 4 glioma | 6 | 10 | 1.000 | 6 | 10 | 1.000 | 11 | 5 | 1.000 |
| WHO grade 3 glioma | 1 | 1 | 1 | 1 | 1 | 1 | |||
| Extent of resection | |||||||||
| GTR, STR | 5 | 5 | 0.367 | 4 | 6 | 1.000 | 8 | 2 | 0.321 |
| PR, B | 2 | 6 | 3 | 5 | 4 | 4 | |||
| Radiotherapy | |||||||||
| CRT | 4 | 7 | 1.000 | 4 | 7 | 1.000 | 6 | 5 | 0.316 |
| PT | 3 | 4 | 3 | 4 | 6 | 1 | |||
| pre-WBC | |||||||||
| < 6,000 | 6 | 6 | 0.316 | 4 | 8 | 0.627 | 8 | 4 | 1.000 |
| 6,000 ≤ | 1 | 5 | 3 | 3 | 4 | 2 | |||
| pre-neutro | |||||||||
| < 3,000 | 5 | 4 | 0.335 | 3 | 6 | 1.000 | 6 | 3 | 1.000 |
| 3,000 ≤ | 2 | 7 | 4 | 5 | 6 | 3 | |||
| Pre-lymph | |||||||||
| < 1,200 | 5 | 2 | 0.049 | 3 | 4 | 1.000 | 7 | 0 | 0.038 |
| 1,200 ≤ | 2 | 9 | 4 | 7 | 5 | 6 | |||
B: biopsy, CRT: conventional radiotherapy, GTR: gross total resection, KPS: Karnofsky performance status, PR: partial resection, pre-lymph: lymphocyte counts before chemoradiotherapy, pre-neutro: neutrocyte counts before chemoradiotherapy, pre-WBC: white blood cell counts before chemoradiotherapy, PT: proton therapy, STR: subtotal resection, WHO: World Health Organization.