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. 2015 Oct 13;11:64. doi: 10.1186/s12990-015-0067-5

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© Betelli et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Afferent driven release of GABA onto low threshold afferent terminals can suppress strong excitatory drive in dorsal horn circuitry. a EPSCs evoked by strong excitatory drive (i.e., a four stimuli train in our experiments) causes strong depression of the second EPSC. b When GABA_A-mediated presynaptic inhibition is absent, as is thought to occur in some chronic pain states, the strong depression on the second EPSC is relieved and the overall level of excitability in dorsal horn circuits is increased