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. 2015 Oct 14;14:163. doi: 10.1186/s12934-015-0354-x

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© Ledesma-Amaro et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Riboflavin overproduction in the engineered A. gossypii. a quatification of riboflavin production in A. gossypii strains. The data are the means of three independent experiments performed in duplicate. b solid MA2 plates of the strains A330, A324 and wild-type of A. gossypii. The strain A330 that was modified both for the underexpression of the ADE12 gene and for the overexpression of five RIB genes afforded the highest riboflavin yield (in yellow)