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. Author manuscript; available in PMC: 2015 Oct 14.
Published in final edited form as: Mayo Clin Proc. 2014 Apr;89(4):563–575. doi: 10.1016/j.mayocp.2014.01.020

Figure 1. Effects of aging on the immune system.

Figure 1

Aging reduces immune competence, naïve T cell numbers, CD28 expression and DNA double strand repair, resulting in immune cells with increased DNA damage and a proinflammatory signature.

DUSP = Dual Specificity Phosphatase