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Traditional and potential therapies for osteoporosis.
| Molecular target | Mechanism of action | Approved agent |
|---|---|---|
| Prenylation | Osteolysis inhibitor | Zoledronic acid and other bisphosphonates |
| RANK/RANKL/OPG axis | Osteoclastogenesis inhibitor | Denosumab |
| Recombinant osteoprotegerin (OPG) | Osteoclastogenesis inhibitor | |
| STA-21 (STAT-3 inhibitor) | Osteoclastogenesis inhibitor | |
| TGF-beta | Osteoclastogenesis inhibitor | |
| Alpha2/Beta1 integrin | Bone homing and drug vehicles |
