Table 3.

Studies investigating cerebral autoregulation during cardiac surgery in conjunction with neurocognitive tests.

Study	Study design	Number of patients	Cerebral autoregulation measures	Time of assessment	Outcome
Patel et al., 1993 [53]	RCT	70	Xenon-133 isotope clearance, CMRO2 (cerebral metabolic rate for oxygen), CERO2 (cerebral extraction ratio for oxygen)	6 weeks	Decline with impaired CA
Patel et al., 1996 [54]	RCT	70	CBF, CBFv, and O2 saturation were measured during 4 phases of surgery	6 weeks	Decline with impaired CA
Govier et al., 1984 [55]	Obsv.	67	Partial pressure of arterial carbon dioxide (PaCO2), clearance of xenon-133	Discharge	No difference
Newman et al., 1994 [12]	Obsv.	215	Xenon-133 clearance, CMRO2, cerebral AV difference (C[AV]O2)	Discharge	No difference

Obsv.: observational.