Table 3.
Pharmacokinetic parameters of dimethoxycurcumin (DMC) in plasma from rats intravenously administering sb-DMC or DMC-PMs at a dose of 10 mg/kg
| Parameter | sb-DMC | DMC-PMs |
|---|---|---|
| Cmax (mg·L−1) | 47.32±2.37 | 50.64±2.53* |
| t1/2 (h) | 0.92±0.03 | 2.81±0.34* |
| AUC0–∞ (mg·h·L−1) | 48.49±1.85 | 132.74±8.17* |
| MRT0–∞ (h) | 1.33±0.05 | 4.05±0.49* |
| V (L·kg−1) | 0.27±0.02 | 0.31±0.04 |
| Cl (L·h−1·kg−1) | 0.21±0.01 | 0.08±0.01* |
Notes: Statistical analysis was performed using a one-way ANOVA followed by a Student’s t-test. Results are presented as mean ± standard deviation, n=6.
*
P<0.05 versus sb-DMC.
Abbreviations: h, hours; sb-DMC, free dimethoxycurcumin (DMC) dissolved in dimethyl sulfoxide; DMC-PMs, dimethoxycurcumin loaded polymeric micelles; Cmax, the maximum concentration; t1/2, plasma half-life; AUC0–∞, area under the curve; MRT0–∞, mean residence time; Cl, clearance; V, volume of distribution; ANOVA, analysis of variance.