Table 4.

Tissue distribution of dimethoxycurcumin (DMC) in nude mice intravenously administered DMC-PMs at a dose of 50 mg/kg

Time (h)	Heart (μg/g)	Liver (μg/g)	Spleen (μg/g)	Lung (μg/g)	Kidney (μg/g)	Brain (μg/g)	Tumor (μg/g)
0.25	5.47±0.30	3.96±0.17	0.63±0.11	0.40±0.02	1.21±0.05	0.26±0.04	1.04±0.12
0.5	2.40±0.11	1.20±0.07	0.55±0.11	1.20±0.08	0.55±0.04	0.18±0.02	0.60±0.09
1	1.21±0.16	0.50±0.04	0.46±0.10	1.54±0.06	0.17±0.02	0.08±0.01	0.24±0.03
2	0.60±0.15	0.12±0.02	0.30±0.01	0.80±0.07	0.09±0.02	0.06±0.01	0.19±0.02
4	0.40±0.01	0.07±0.01	0.18±0.01	0.34±0.03	0.04±0.01	0.05±0.01	0.09±0.01
8	0.18±0.02	0.03±0.01	0.07±0.02	0.16±0.02	0.01±0.01	0.04±0.02	0.05±0.02

Note: Results are presented as mean ± standard deviation, n=4.

Abbreviations: h, hours; DMC-PMs, dimethoxycurcumin-loaded polymeric micelles.