Figure 4.
Silica quantification by ICP-MS.
Notes: (A) Si content (μg Si/g of tissue) in the blood, liver, spleen, kidneys, lung, and heart removed at 24 hours, 72 hours, 1 week, and 2 weeks postintravenous injection compared to control mice. (B) Correlation between values obtained by ICP-MS (μg Si/g) and radioactivity quantification using the γ-counter. Coefficient of determination (R2) values for linear correlation was reported for each organ. (C) Cumulative percentage of Si in the urine and feces collected at 24 hours, 1 week, 2 weeks, and 1 month postinjection of silica nanoparticles. *P<0.05 vs control.
Abbreviation: ICP-MS, inductively coupled plasma mass spectrometry.