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Design and structure of chemically modified gap-primers. Left panel: molecular structures of the abasic gaps; right panel: sequence and structure of hairpin and loop gap-primers. (A) AP1 (dSpacer1) primers harboring a single tetrahydrofuran-based abasic site mimic. (B) AP3 (dSpacer3) primers harboring three tetrahydrofuran-based abasic site mimics. (C) S9 (PEG-150) primers harboring a triethylene glycol-based spacer.
