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. 2015 Oct 10;43(18):9065–9075. doi: 10.1093/nar/gkv861

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — (A) Nucleotides in the mtPAP structures from Mol-B are shown with the simulated annealing Fo-Fc omit map (blue mesh), contoured at 3.0 σ for ATPγS, 2.0 σ for UTP and CTP, and 2.5 σ for GTP. (B) The relative positions of all four bound triphosphate ribonucleotides derived from superpositioning the mtPAP nucleotide-bound structures. (C–E) Key ribose/base interactions between mtPAP and UTP, GTP, and CTP, as found in Mol-B in the bound structures of mtPAP. The same interactions were observed in Mol-A, except in the case of the GTP where only the triphosphate moiety was modeled. (F) Surface representation of mtPAP nucleotide binding pocket with ATPγS shown as a stick model.