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Comparison between open-apo and closed-ATP crystal structures. NS3h is represented with ribbons, while ATP and ssRNA are displayed with sticks. The gap between domain 1 (D1) and domain 2 (D2) is larger for the open conformation. The distance between centers of mass of D1 and D2 is ∼29 Å in the open structure and ∼26 Å in the closed one. Water and ions are not shown.
