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. 2015 Oct 10;43(18):8664–8672. doi: 10.1093/nar/gkv942

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Physicochemical and biological properties of hsiRNA, Guanabenz, and Guanabenz derivatives (A) Characterization of nanoaggregates formed by hsiRNA and Guanabenz. (Top) Size distribution and intensity measured by dynamic light scattering (Nano-ZS, Malvern). N.D. = not detectable; PdI = polydispersity index. (Bottom right) hsiRNA nanoparticle size and morphology examined by transmission electron microscopy following incubation with 500 or 750 μM Guanabenz (Tecnai Spirit 12, FEI, 43,000X). Scale bar = 0.2 μM. (B) Chemical derivatives and/or functional analogs of Guanabenz (1) (C) IC₅₀ values of PPIB-targeting hsiRNA following treatment with Guanabenz and derivatives [100 μM (1–4, 7,8) or 12.5 μM (5,6)] or 1% DMSO. Derivitization results in loss of effect of Guanabenz on hsiRNA IC₅₀.