FIG. 4.
Optimal migration distance and velocity of GSCs in collagen-I occur at stiffness levels in the range of normal brain. (A) Migration distance (at 72 h) and (B) migration velocity (at 24 h) are modulated by matrix stiffness (G′). Values marked as * are statistically different from **, † are statistically different from ††, p-value < 0.05. Oligomer matrices with G′ of 225 Pa (oligomer 1.5 mg/mL) and 397 Pa (oligomer 2.0 mg/mL) supported the greatest migration distance and velocity compared to other collagen matrices. Error bars indicate ± SEM.