FIG. 7.

(A) GSC neurospheres exhibited multiple migration modes in the composite matrix as the single-cell migration mode across the 3D matrix and collective strand migration along the topographical cues present in the matrix. Staining for nuclei was incomplete due to the density of the neurosphere. Scale bars 100 μm. (B) Distance of migration along the rods increases with time and present values comparable to Matrigel 50%, n = 4, error bars indicate ± SEM. (C) Velocity of migration along the rods slowly decreases with time presenting values comparable with other types of matrices such as oligomer 2 mg/mL, n = 4, error bars indicate ± SEM. (D) Comparison of GSC maximum distance of migration in different types of matrices at 72 h, n = 9. (E) Comparison of GSC velocity of migration in different types of matrices at 24 h, n = 9. Color images available online at www.liebertpub.com/tea