Fig 5. D₂-dopaminergic receptor-mediated regulation of critical hepatocyte factors that regulate CYP1A1, CYP1A2 and CYP1B1.

Assessments of the effects induced by the selective dopamine D₂-antagonist sulpiride on aryl hydrocarbon receptor [1], aryl hydrocarbon receptor repressor (AhRR), aryl hydrocarbon receptor nuclear translocator (ARNT) and heat shock protein 90 (HSP90) relative mRNA expression by using quantitative PCR assays. Bonferroni’s correction and Tukey post-hoc tests took place in the comparisons of the data presented here. In particular, comparisons of data (Relative ARNT and AhRR mRNA levels) between the group of controls (C) and SULP took place using the Bonferroni’s and Tukey tests and no difference was found. (C vs SULP, C vs B[a]P and B[a]P vs (B[a]P+SULP)). C: controls treated with normal saline; SULP: sulpiride (dopamine D₂-antagonist); B[a]P: benzo[a]pyrene; OIL: olive oil; *P<0.05, **P<0.01, #P<0.005, ***P<0.001.