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Analytical Cellular Pathology (Amsterdam) logoLink to Analytical Cellular Pathology (Amsterdam)
. 2011 Dec 7;35(3):145–163. doi: 10.3233/ACP-2011-0048

Modern Trends in Imaging VI: Raman Scattering in Pathology

Zachary J Smith 1, Thomas R Huser 1,2, Sebastian Wachsmann-Hogiu 1,3,*
PMCID: PMC4605518  PMID: 22155991

Abstract

Raman scattering is the inelastic scattering of light by chemical bonds, and can therefore show molecular specificity. It can be used both in pure spectroscopy mode, and in imaging mode. While many applications of Raman spectroscopy and imaging in the biomedical field have been so far demonstrated, the use of this technology for pathology applications is still in early stages. In this paper we review some of the most important recent developments in this field, including a description of relevant technologies, applications to molecular sensing, characterization of cells and tissues of interest, and disease detection via Raman scattering.

Keywords: Raman scattering, imaging, molecular sensing, diagnosis


Articles from Analytical Cellular Pathology (Amsterdam) are provided here courtesy of Wiley

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