Figure 2. TTN transcript variability in heart.

A.) Human titin (blue) spans half the sarcomere with the amino-terminus anchored at the Z disk and the carboxy-terminus located at the M line. B.) TTN produces a number of transcripts, including the cardiac specific N2BA and N2B that lack portions of the I-band region of titin. C.) Exon usage identified by Roberts et al. in LV from DCM hearts. Red areas indicate that all exons are transcribed in hearts, while lighter colors indicate less exon usage ²².