Appendix Table 2.

Predictors of All-Cause Mortality^*

Variable	Unadjusted OR (95% CI)	Multivariable Model 1^† OR (95% CI)	Multivariable Model 2^‡ OR (95% CI)
Total ambulatory physician visits to PCP
0–1	1.00 (reference)	1.00 (reference)	1.00 (reference)
2–4	0.75 (0.73–0.78)	0.82 (0.79–0.85)	0.88 (0.85–0.92)
5–10	0.76 (0.74–0.79)	0.79 (0.76–0.82)	0.88 (0.84–0.91)
≥11	0.90 (0.88–0.93)	0.81 (0.78–0.85)	0.92 (0.88–0.95)
Total ambulatory physician visits to non-PCP
0–1	1.00 (reference)	1.00 (reference)	1.00 (reference)
2–4	0.85 (0.83–0.88)	0.82 (0.79–0.85)	0.86 (0.83–0.89)
5–10	0.89 (0.86–0.91)	0.78 (0.76–0.81)	0.84 (0.81–0.87)
≥11	1.11 (1.07–1.15)	0.82 (0.79–0.86)	0.91 (0.88–0.95)
Sex
Male	1.00 (reference)	1.00 (reference)	1.00 (reference)
Female	0.53 (0.52–0.54)	0.53 (0.52–0.55)	0.53 (0.52–0.55)
Race/ethnicity
White, non-Hispanic	1.00 (reference)	1.00 (reference)	1.00 (reference)
Black, non-Hispanic	1.36 (1.30–1.42)	1.14 (1.08–1.20)	1.13 (1.07–1.19)
Hispanic	0.57 (0.52–0.63)	0.48 (0.43–0.53)	0.46 (0.41–0.51)
Asian or Pacific Islander	0.57 (0.53–0.61)	0.47 (0.43–0.51)	0.45 (0.42–0.49)
Native American	0.85 (0.68–1.07)	0.68 (0.53–0.87)	0.64 (0.50–0.83)
Other	0.86 (0.78–0.95)	0.76 (0.68–0.84)	0.75 (0.67–0.83)
Unknown	0.98 (0.76–1.27)	0.92 (0.70–1.23)	0.91 (0.68–1.21)
Quintile of education level (derived at ZIP code level)
1 (lowest)	1.00 (reference)	1.00 (reference)	1.00 (reference)
2	0.90 (0.87–0.93)	0.88 (0.84–0.91)	0.88 (0.84–0.92)
3	0.89 (0.85–0.92)	0.83 (0.79–0.87)	0.85 (0.81–0.89)
4	0.80 (0.77–0.83)	0.74 (0.70–0.78)	0.76 (0.72–0.80)
5 (highest)	0.67 (0.65–0.70)	0.61 (0.58–0.65)	0.64 (0.60–0.68)
Quintile of median household income (derived at ZIP code level)
1 (lowest)	1.00 (reference)	1.00 (reference)	1.00 (reference)
2	0.97 (0.94–1.01)	1.11 (1.07–1.16)	1.12 (1.07–1.17)
3	0.93 (0.90–0.97)	1.12 (1.06–1.17)	1.12 (1.07–1.17)
4	0.92 (0.89–0.95)	1.19 (1.13–1.25)	1.18 (1.12–1.25)
5 (highest)	0.81 (0.78–0.84)	1.21 (1.14–1.29)	1.21 (1.14–1.29)
Type of metropolitan statistical area
Large metropolitan	1.00 (reference)	1.00 (reference)	1.00 (reference)
Metropolitan	0.88 (0.84–0.91)	0.87 (0.84–0.91)	0.87 (0.83–0.91)
Urban	0.93 (0.88–0.98)	0.86 (0.81–0.91)	0.86 (0.81–0.92)
Less urban	0.87 (0.82–0.91)	0.78 (0.74–0.83)	0.78 (0.73–0.83)
Rural	0.80 (0.73–0.88)	0.70 (0.64–0.78)	0.69 (0.63–0.76)
Charlson comorbidity index
0	1.00 (reference)	1.00 (reference)	1.00 (reference)
1	1.61 (1.56–1.66)	1.77 (1.72–1.83)	1.76 (1.70–1.82)
≥2	3.07 (2.96–3.17)	3.36 (3.23–3.49)	3.34 (3.21–3.47)
Influenza vaccination
No	1.00 (reference)	1.00 (reference)	1.00 (reference)
Yes	0.83 (0.81–0.85)	0.83 (0.81–0.85)	0.87 (0.85–0.89)
Previous CRC screening
No	1.00 (reference)	NA	1.00 (reference)
Yes	0.64 (0.62–0.65)	NA	0.71 (0.69–0.73)
Previous polypectomy
No	1.00 (reference)	NA	1.00 (reference)
Yes	0.60 (0.58–0.63)	NA	0.72 (0.69–0.75)

CRC = colorectal cancer; NA = not applicable; OR = odds ratio; PCP = primary care physician.

The total number of deaths from all causes matching control participants was 121 070.

^†

Adjusted for primary care visits, non–primary care visits, sex, race/ethnicity, quintile of education level, quintile of median household income, urban or rural residence, comorbid conditions, and influenza vaccination.

^‡