Table 2. Clinical and microbiological factors and their association with nasopharyngeal pneumococcal density.
Univariate analysis on 57 patients if not otherwise stated.
| Factor | log10 DNA copies/mL | |||
|---|---|---|---|---|
| No. with factor/No. without factor | With factor, median pneumococcal density (interquartile range) | Without factor, median pneumococcal density (interquartile range) | P- value | |
| Female gender | 27/30 | 7.05 (6.22–7.95) | 6.72 (5.59–7.66) | 0.35 |
| Age ≥65 years | 34/23 | 6.77 (5.78–7.66) | 6.86 (6.29–7.74) | 0.49 |
| Co-morbidity a | 33/24 | 6.71 (6.09–7.66) | 6.84 (6.14–7.86) | 0.72 |
| Smoking, current or previous | 35/22 | 6.83 (6.22–7.67) | 6.79 (5.95–7.76) | 0.83 |
| Viral co-infection | 14/43 | 7.35 (6.62–7.76) | 6.71 (5.59–7.67) | 0.31 |
| Pneumonia severity index risk class IV-V | 23/34 | 7.47 (6.24–7.97) | 6.58 (5.95–7.56) | 0.04 |
| Symptoms ≥2 days prior to admission | 37/20 | 7.05 (6.29–7.71) | 6.26 (5.46–7.70) | 0.10 |
| Respiratory rate ≥ 30 | 20/37 | 7.22 (6.28–8.10) | 6.66 (5.95–7.65) | 0.12 |
| Positive blood culture | 12/45 | 6.94 (6.02–8.10) | 6.73 (6.22–7.66) | 0.61 |
| Positive urine antigen test | 33/24 | 6.71 (5.78–7.67) | 6.99 (6.30–7.73) | 0.56 |
| Bilateral chest X-ray infiltrates | 16/41 | 7.36 (6.70–8.00) | 6.62 (6.07–7.66) | 0.10 |
| Admission to intensive care unit | 3/54 | 8.06 (7.67–9.50) | 6.72 (6.07–7.66) | 0.03 |
| Serotype with high degree of encapsulation b | 26/23 | 7.47 (6.42–7.79) | 6.66 (6.22–7.97) | 0.31 |
| Medium/high S-Ig titer to the patient´s own serotype | 30/17 | 7.61 (6.39–8.06) | 6.66 (5.71–7.20) | 0.008 |
a Solid tumor, blood malignancy, liver disease, renal disease, chronic obstructive pulmonary disease, heart disease, stroke, diabetes.
b Serotypes 3, 6B, 11A, 12F, 19A, 19F, 23F, and 35B.