Table 4. Effect of Growth hormone (1mg/kg s.c.; once daily for 1 wk) on oxidative stress markers in rats subjected to single dose whole-body irradiation (3.2 Gy).
| Treated groups | GSH (μmol/g wet tissue) | MDA(nmol/g wet tissue) | GPx (U/ mg protein) | GSHRx (mU/mg protein) |
|---|---|---|---|---|
| Control | 2.64± 0.067 b | 9.94 ±0.570 b | 0.23±0.012 b | 1.78±0.082 b |
| IR | 0.51 ± 0.017 a | 38.90 ±1.20 a | 0.061±0.004 a | 1.07±0.043 a |
| IR/GH | 1.27 ±0.011 a,b | 26.02±1.02 a,b | 0.130± 0.012 a,b | 1.35±0.004 a,b |
| GH | 2.56 ± 0.140 b | 13.35± 1.36 b | 0.195 ±0.007 b | 1.69±0.033 b |
-Data are mean ± SEM (n = 6).
- a or b: Significantly different from control or radiation group, respectively at P <0.05 using one-way ANOVA followed by Tukey–Kramer as a post-hoc test
IR: irradiation; IR/GH: irradiation/Growth hormone; GH: Growth hormone; GSH, reduced glutathione; MDA, malondialdehyde; GPx, glutathione peroxidase; GSHRx, glutathione reductase.