Table 2. Immunogenicity (rSBA) of MenPF-1 vaccine in mice (dose levels 1.0–10.0 μg per dose).
| Dose | Serum Bactericidal Titre (GMT) rabbit complement | |||
|---|---|---|---|---|
| μg, (2 doses) | SMenPF1.2 fetAp 17bp | 3043 fetA::kan | 3312 fetAp 17bp, porA::ermC | 3311 fetA::kan, porA::ermC |
| 1.0 | 1383 (921–2078) | 1233 (817–1862) | 10 (5–19) | 5 (4–6) |
| 2.5 | 2097 (1415–3107) | 795 (341–1854) | 25 (14–43) | 7 (5–10) |
| 5.0 | 2767 (1982–3862) | 3566 (2942–4322) | 12 (10–14) | 11 (6–17) |
| 10.0 | 1933 (1197–3123) | 1723 (1252–2372) | 16 (12–22) | 13 (9–19) |
Serum bactericidal titres of sera (pools of four mice, five pools per group) were determined against four target strains using rabbit sera as the complement source. The table shows geometric mean titres, with the 95% confidence intervals of the mean in parentheses. Mice were given two doses of four dose levels or an adjuvant only control. Note that the data from mice given two doses of 2.5 μg protein per dose is included in Table 4 for comparison, as the immunizations were performed concomitantly.