Table 4. Immunogenicity (rSBA) of MenPF-1 vaccine in mice (number of doses).

Number of doses	Serum Bactericidal Titre (GMT) rabbit complement
2.5 μg /dose	SMenPF1.2 fetAp 17bp	3043 fetA::kan	3312 fetAp 17bp,porA::ermC	3311 fetA::kan, porA::ermC
1	253 (200–321)	32 (19–54)	11 (9–13)	6 (5–8)
2	2097 (1415–3107)	795 (341–1854)	25 (14–43)	7 (5–10)
3	1683 (996–2844)	1204 (748–1939)	22 (15–31)	11 (7–16)
4	3366 (2458–4610)	1552 (950–2535)	97 (61–155)	25 (16–38)

Serum bactericidal titres of sera (pools of four mice, five pools per group) were determined against four target strains using rabbit sera as the complement source. The table shows geometric mean titres, with the 95% confidence intervals of the mean in parentheses. Mice were given 1, 2, 3 or 4 doses of 2.5 μg protein per dose. Note that the data from mice given two doses of 2.5 μg protein per dose is included in Table 2 for comparison, as the immunizations were performed concomitantly.