Table 2. Association between serum adiponectin levels and eGFR, considered as a continuous trait.

	SGR (N = 878)		FG sample (N = 365)		Pooled data meta-analysis (N = 1,243)*
	β (SE)	P	β (SE)	P	β (SE)	P
Model 1	-3.26 (0.64)	<0.0001	-5.70 (1.28)	<0.0001	-3.99 (0.59)	<0.0001
Model 2	-1.22 (0.65)	0.037	-3.91 (1.21)	0.003	-2.19 (0.59)	0.0001

SGR: San Giovanni Rotondo; FG: Foggia. p value obtained from lnGFR.

The β linear coefficients represent the change in eGFR level (ml/min/1.73m²) for 1.SD increase in adiponectin. SE: standard error.

Model 1: unadjusted.

Model 2: adjusted by sex, smoking habits, BMI, waist circumference, diabetes duration, HbA1c, ACR and anti-hyperglycemic, anti-hypertensive and anti-dyslipidemic treatments.

*Since the effect in SGR tended to be different than that in FG sample (p for β values heterogeneity being = 0.15), individual data meta-analysis was carried out in a conservative fashion by using random effects.

Pooled analysis were adjusted by study sample.