Table 4. Median (range) and p-values for the transcription of target genes within liver samples.
Genes (Liver) | Controls | Group 1 (6 months post infection) | Group 2 (15 months post infection) | Controls vs Group 1 | Controls vs Group 2 | Group 1 vs Group 2 |
---|---|---|---|---|---|---|
TLR2 | 96.58 (84.42–1392.73) | 550.77 (128.43–903.51) | 366.63 (201.42–892.36) | p = 0.001* | p = 0.007* | p = 0.764 |
TLR3 | 239.34 (159.73–3256.20) | 298.42 (95.98–831.85) | 214.97 (103.31–288.47) | p = 0.809 | p = 0.962 | p = 0.695 |
TLR4 | 162.66 (118.09–2348.42) | 203.00 (47.76–400.73) | 132.04 (90.40–303.30) | p = 0.148 | p = 0.315 | p = 0.417 |
TLR9 | 556.32 (336.05–7636.49) | 1387.00 (192.72–7405.74) | 497.47 (149.37–956.36) | p = 0.196 | p = 0.109 | p = 0.502 |
IL-17 | 0.58 (0.27–6.98) | 0.49 (0.08–1.99) | 1.80 (1.63–17.4) | p = 0.377 | p = 0.571 | p = 0.060 |
IL-22 | 6.63 (3.36–76.40) | 0.46 (0.12–5.73) | 2.83 (2.10–5.05) | p<0.001* | p = 0.033 | p<0.001* |
FoxP3 | 2.25 (2.05–32.54) | 3.59 (0.81–11.61) | 2.04 (1.35–36.79) | p = 0.480 | p = 0.232 | p = 0.563 |
Significant Bonferroni corrected p-values are highlighted bold (p< = α/3).
(*) p-value<0.016.