Table 6. Median (range) and p-values for the transcription of target genes within spleen samples.
Genes(Spleen) | Controls | Group 1 (6 months post infection) | Group 2 (15 months post infection) | Controls vs Group1 | Controls vs Group 2 | Group 1 vs Group 2 |
---|---|---|---|---|---|---|
TLR2 | 3007.40 (1798.94–3287.07) | 2383.58 (1550.86–4654.14) | 2544.15 (1568.13–5424.72) | p = 0.118 | p = 0.417 | p = 0.627 |
TLR3 | 1028.55 (517.35–2312.03) | 741.91 (157.04–2191.08) | 367.96 (147.59–1120.88) | p = 0.515 | p = 0.088 | p = 0.085 |
TLR4 | 3765.41 (2733.20–4570.21) | 1157.07 (483.38–2924.33) | 920.75 (445.67–1293.38) | p = 0.002* | p = 0.005* | p = 0.182 |
TLR9 | 980.30 (560.20–1222.08) | 6866.13 (778.07–119451.01) | 2316.45 (395.51–26120.09) | p<0.001* | p = 0.364 | p = 0.167 |
IL-17 | 1.46 (0.53–6.57) | 2.27 (0.66–12.49) | 1.84 (1.05–3.19) | p = 0.393 | p = 0.905 | p = 0.273 |
IL-22 | 17.67 (11.68–35.42) | 4.33 (0.94–22.27) | 3.04 (0.18–20.26) | p<0.001* | p = 0.002* | p = 0.661 |
FoxP3 | 43.73 (20.67–85.44) | 62.78 (7.51–210.02) | 39.94 (18.33–101.60) | p = 0.222 | p = 0.758 | p = 0.139 |
Significant Bonferroni corrected p-values are highlighted bold (p< = α/3).
(*)p-value<0.016.