Table 2. Recipient and Donor Demographics.
| CNI Minimization vs. Withdrawal | Minimization | Withdrawal |
|---|---|---|
| # of starting patients | 88 | 90 |
| Censored prior to 6 months 1 | 5 | 6 |
| Not withdrawn due to: | ||
| rejection | N/A 3 | 5 |
| refused or could not afford sirolimus | N/A | 4 |
| PI discretion | N/A | 4 |
| BK virus | N/A | 2 |
| death | N/A | 1 |
| polycystic liver disease | N/A | 1 |
| intractable mouth ulcers | N/A | 1 |
| myocardial infarction | N/A | 1 |
| Censored for rejection ≤6 months | 5 | N/A |
| # patients on treatment | 78 | 65 |
| Recipient Demographics ITT n = | 88 | 90 |
| Age at transplantation (years) | 46.5 ± 11.6 | 47.9 ± 12.1 |
| BMI | 28.2 ± 5.1 | 28.9 ± 5.5 |
| BMI > 30 | 33 (38%) | 37 (41%) |
| Males | 59 (67%) | 62 (69%) |
| Living donor (related/unrelated) | 28 / 25 | 32 / 23 |
| Deceased donor (DD) | 35 (40%) | 35 (39%) |
| DD cold ischemia (hours) | 14.5 ± 6.3 | 14.5 ± 8.2 |
| PRA (%) | 0.8 ± 3.8 | 1.2 ± 7.0 |
| Donor/Recipient height ratio (ITT) | 0.98 ± 0.08 | 1.0 ± 0.07 |
| Donor/Recipient height ratio (On-treatment) | 0.98 ± 0.08 | 1.0 ± 0.07 |
| Antigen mismatch | 3.3 ± 1.9 | 3.5 ± 1.7 |
| CNI withdrawn | N/A | 65 (72%) |
| Race (Non-Caucasian/Asian) | 11 (13%) | 10 (11%) |
| CMV serostatus (D+/R- or D+/R+) | 54 (61%) | 53 (59%) |
| Donor Demographics | ||
| Age at procurement (years) | 42.6 ± 12.1 | 39.3 ± 13.1 |
| Males | 41 (47%) | 37 (41%) |
| BMI | 27.5 ± 4.9 | 27.7 ± 4.7 |
| Final creatinine (mg/dl) | 1.0 ± 0.5 | 1.0 ± 0.5 |
| DD grade 2 A | 11 (13%) | 9 (10%) |
| DD grade 2 B | 14 (16%) | 12 (13%) |
| DD grade 2 C | 6 (7%) | 8 (9%) |
| DD <18 years of age | 4 (5%) | 6 (7%) |
1Reasons for censoring patients before six months were equally distributed and included withdrawal of consent, scheduled pancreas transplantation, transfer of care, death.
2Nyberg deceased donor scoring algorithm [62].
3Not Applicable.